Effect of Aqueous Extract of Giant Horsetail (Equisetum giganteum L.) in Antigen-Induced Arthritis

Mirian Farinon1, 4, Priscila Schmidt Lora1, 2, Leandro Nicolodi Francescato3, Valquiria Linck Bassani3, AmÉlia Teresinha Henriques3, Ricardo Machado Xavier1, 2, Patricia Gnieslaw de Oliveira*, 1, 2
1 Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350 – CEP 90035-903, Bairro Rio Branco, Porto Alegre/RS, Brazil
2 Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2400 – CEP 90035-003, Bairro Santa CecÍlia, Porto Alegre/RS, Brazil
3 Departamento de ProduÇÃo de MatÉria-Prima, Faculdade de FarmÁcia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752 – CEP 90610-000, Bairro Santana, Porto Alegre/RS, Brazil
4 Instituto de CiÊncias BÁsicas da SaÚde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500 – CEP 90010-170, Bairro Centro, Porto Alegre/RS, Brazi

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© Farinon et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Hospital de Clínicas de Porto Alegre, Serviço de Reumatologia, Rua Ramiro Barcellos, 2350, sala 645, Zip code 90035-003 - Porto Alegre, Brazil; Tel: +55-51-33598837; Fax: +55-51-33598340; E-mail:


Equisetum giganteum is a plant used in traditional medicine as diuretic. From our knowledge this is the first time this plant is tested in an in vivo model of acute inflammation. To evaluate the effect of aqueous extract of giant horsetail (AEGH) as immunomodulatory therapy, antigen-induced arthritis (AIA) was generated in mice with methylated bovine serum albumin (mBSA). Inflammation was evaluated by articular nociception, leukocytes migration and lymphocyte proliferation. AEGH reduced nociception at 3, 6 and 24 h (P < 0.01), decreased leukocyte migration (P < 0.015), and inhibited lymphocyte proliferation stimulated with Concanavalin A and Lipopolysaccharide (P < 0.05). In conclusion, AEGH has an anti-inflammatory potential in acute model of inflammation, as well as immunomodulatory effect on both B and T lymphocytes, with an action independent of cytotoxicity.

Keywords: : Equisetum giganteum L., aqueous extract of giant horsetail (AEGH), Antigen-Induced Arthritis (AIA), immunomodulatory therapy..