RESEARCH ARTICLE
Increased RP105-Negative B Cells in IgG4-Related Disease
S Koarada*, S Tashiro, N Nagao, R Suematsu, A Ohta, Y Tada
Article Information
Identifiers and Pagination:
Year: 2013Volume: 7
First Page: 55
Last Page: 57
Publisher ID: TORJ-7-55
DOI: 10.2174/1874312901307010055
Article History:
Received Date: 25/5/2013Revision Received Date: 5/7/2013
Acceptance Date: 8/7/2013
Electronic publication date: 23/8/2013
Collection year: 2013
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Four patients with IgG4-related disease (IgG4-RD) showed increased percentages of RP105-negative B cells in the peripheral blood. Case 1: A 66-year-old man having retroperitoneal fibrosis had 18.8% of RP105-negative B cells. Oral prednisolone improved the affected lesions and the percentage of RP105-negative B cells decreased (3.2%) after the treatment. Case 2: A 53-year-old man with retroperitoneal fibrosis had 27.9% of RP105-negative B cells. Case 3: A 38-year-old man with follicular hyperplasia showed increased percentage of RP105-negative B cells (8.3%). Case 4: A 60-year-old man with interstitial nephritis had 27.5% of RP105-negative B cells. The treatment decreased the numbers of RP105-negative B cells. Increased numbers of RP105-negatvie B cells is possibly associated with disease activity of IgG4-RD. Analysis of expression of RP105 on B cells may be helpful in evaluation of disease activity of IgG4-RD.
