RESEARCH ARTICLE
Profiling of HLA-B Alleles for Association Studies with Ankylosing Spondylitis in the Chinese Population
Lin Yi1, 2, §, Jiucun Wang3, 5, §, Xinjian Guo1, Maribel G. Espitia1, Enuo Chen1, Shervin Assassi1, Li Jin3, Hejian Zou4, 5, * , John D. Reveille 1, Xiaodong Zhou1, §
Article Information
Identifiers and Pagination:
Year: 2013Volume: 7
First Page: 51
Last Page: 54
Publisher ID: TORJ-7-51
DOI: 10.2174/1874312920130628001
Article History:
Received Date: 22/5/2013Revision Received Date: 19/6/2013
Acceptance Date: 24/6/2013
Electronic publication date: 19 /8/2013
Collection year: 2013

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Human leucocyte antigen (HLA) B*27 is a susceptibility allele to ankylosing spondylitis (AS). However, major AS-associated subtypes of HLA-B*27 and other HLA-B alleles vary in different ethnic populations. Herein, we examined HLA-B alleles in a total of 360 AS patients and 350 controls of Chinese Han ancestry. The HLA-B genotyping was performed with sequence-based typing (SBT) method. Six HLA-B*27 subtypes B*27:04, B*27:05, B*27:07, B*27:08, B*27:10 and B*27:15 were observed in the cohorts. HLA-B*27:04:01 and -B*27:05:02 appeared significantly increased in AS patients, which indicated as two major susceptibility alleles to AS. Homozygous B*27 was observed only in AS patients. There are 30 HLA-B alleles identified in the studies. HLA-B*15, especially B*15:01:01:01, appeared as the major allele type in the Chinese controls. Some common HLA-B alleles such as HLA-B*15, B*13, B*46 and B*51 were significantly reduced in Chinese AS patients. In conclusion, the studies profiled the HLA-B alleles, and identified major susceptibility subtypes of B27 to AS in Han Chinese population