New Insights into the Mechanism of Notch Signalling in Fibrosis



Niloufar Kavian 1, Amélie Servettaz 2, Bernard Weill 1, Frédéric Batteux*, 1
1 Laboratoire d'immunologie, EA 1833, Université Paris Descartes, Sorbonne Paris-Cité, Faculté de Médecine, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), France
2 Service de Médecine Interne, Maladies Infectieuses, Immunologie Clinique, Faculté de Médecine de Reims, Hôpital Robert Debré, 51092 Reims cedex, France


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© Kavian et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Laboratoire d’Immunologie, UPRES EA1833, 24, rue du faubourg St Jacques 75679 Paris cedex 14, France; Tel: +33 (0) 1 58 41 21 41; Fax: +33 (0) 1 58 41 20 08; E-mail: frederic.batteux@cch.aphp.fr


Abstract

The Notch pathway is an evolutionary conserved signalling mechanism that regulates cellular fate and development in various types of cells. The full spectrum of Notch effects has been well studied over the last decade in the fields of development and embryogenesis. But only recently several studies emphasized the involvement of the Notch signalling pathway in fibrosis. This review summarizes the structure and activation of the Notch family members, and focuses on recent findings regarding the role of Notch in organ fibrogenesis, in humans and in animal models.

Keywords: Notch, fibrosis, systemic sclerosis, scleroderma, fibroblasts, epithelial cells, epithelial-mesenchymal transition, reactive oxygen species..