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New Insights into the Mechanism of Notch Signalling in Fibrosis
Niloufar Kavian 1
Amélie Servettaz 2
Bernard Weill 1
Frédéric Batteux, *
, 1
Authors Info & Affiliations
, 1
Authors Info & Affiliations
Abstract
The Notch pathway is an evolutionary conserved signalling mechanism that regulates cellular fate and development in various types of cells. The full spectrum of Notch effects has been well studied over the last decade in the fields of development and embryogenesis. But only recently several studies emphasized the involvement of the Notch signalling pathway in fibrosis. This review summarizes the structure and activation of the Notch family members, and focuses on recent findings regarding the role of Notch in organ fibrogenesis, in humans and in animal models.
Keywords: Notch, fibrosis, systemic sclerosis, scleroderma, fibroblasts, epithelial cells, epithelial-mesenchymal transition, reactive oxygen species..
