RESEARCH ARTICLE
The Role of TGF-β Receptors in Fibrosis
Sashidhar Nakerakanti , Maria Trojanowska*
Article Information
Identifiers and Pagination:
Year: 2012Volume: 6
Issue: Suppl 1
First Page: 156
Last Page: 162
Publisher ID: TORJ-6-156
DOI: 10.2174/1874312901206010156
Article History:
Received Date: 3/3/2012Revision Received Date: 27/3/2012
Acceptance Date: 4/4/2012
Electronic publication date: 15/6/2012
Collection year: 2012

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Recent advances in defining TGF-β signaling pathways have provided a new level of understanding of the role of this pleiotropic growth factor in the development of fibrosis. Here, we review selected topics related to the profibrotic role of TGF-β . We will discuss new insights into the mechanisms of ligand activation and the contribution of Erk1/2 MAPK, PI3K/FAK, and Endoglin/Smad1 signaling pathways to the process of fibrosis. There is growing evidence of the disease-specific alterations of the downstream components of the TGF-β signaling pathway that may be explored for the future therapeutic interventions.