Prevalence of Anticardiolipin Antibodies in Pregnancies with History of Repeated Miscarriages



Ligia Cosentino Junqueira Franco Spegiorin1, Eloísa A Galão1, Lúcia Buchalla Bagarelli1, Antonio Hélio Oliani1, José Maria Pereira de Godoy*, 2
1 Department of Gynecology of São José do Rio Preto Medicine School of São Paulo (FAMERP), Brazil
2 Department of Cardiology and Cardiovascular Surgery in Medicine School of São José do Rio Preto and CNPq (National Council for Research and Development), Brazil


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© Spegiorin et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Cardiology and Cardiovascular Surgery in Medicine School of São José do Rio Preto and CNPq (National Council for Research and Development), Rua Floriano Peixoto, 2950, São José do Rio Preto, Zipe Code: 15010-020, SP, Brazil; Tel: 55 17 32326362; E-mail: godoyjmp@riopreto.com.br


Abstract

Aim:

This study aimed at evaluating the prevalence of high anticardiolipin antibody and lupus anticoagulant levels in women with histories of at least two miscarriages.

Methods:

The presence of high anticardiolipin antibody and lupus anticoagulant levels were evaluated in 52 patients with ages between 17 and 41 (mean 26.7 years old) who had histories of repeated miscarriages.

Results:

High anticardiolipin antibody levels were identified in 55.77% and lupus anticoagulant levels in 2% of the individuals.

Conclusion:

In conclusion, women who suffer from repeated miscarriages present with a high prevalence of anticardiolipin antibodies. Further studies on this issue are crucial as these antibodies are associated with hypercoagulability and thus increased the risk of thromboembolic events.

Keywords: Repetitive miscarriage, thromboembolism, anticardiolipin antibodies, lupus, anticoagulant..