Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
Doris M Kraemer*, 1, Hans-Peter Tony2
Identifiers and Pagination:Year: 2010
First Page: 24
Last Page: 27
Publisher ID: TORJ-4-24
Article History:Received Date: 8/3/2010
Revision Received Date: 12/3/2010
Acceptance Date: 19/4/2010
Electronic publication date: 13/5/2010
Collection year: 2010
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE.