Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data

Pillai , Sruti; Littlejohn, Geoffrey

Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data

Sruti Pillai , Geoffrey Littlejohn^*

Departments of Rheumatology and Medicine, Monash Health and Monash University, 246 Clayton Road, Clayton, Victoria, 3168, Australia

Article Information

Identifiers and Pagination:

Year: 2014
Volume: 8
First Page: 116
Last Page: 128
Publisher ID: TORJ-8-116
DOI: 10.2174/1874312901408010116

Article History:

Received Date: 24/4/2014
Revision Received Date: 21/10/2014
Acceptance Date: 8/11/2014
Electronic publication date: 19 /12/2014
Collection year: 2014

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© Pillai and Littlejohn; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Suite H, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia; Tel: 613 95942575; Fax: 613 95945588; E-mail: geoff.littlejohn@monash.edu

Objectives:

We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH.

Method:

We identified studies in our personal database and PubMed using the following keywords in various combinations: “diffuse idiopathic skeletal hyperostosis”, “ankylosing hyperostosis”, “Forestier’s disease”, “diabetes”, “insulin”, “obesity”, “metabolic”, “growth factors”, “adipokines”, “glucose tolerance” and “chondrocytes”.

Results:

We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH.

Conclusion:

Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.

Keywords: Bone, diabetes, DISH, diffuse idiopathic skeletal hyperostosis, growth factors, insulin, metabolic, obesity..

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RESEARCH ARTICLE

Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data

Article Information

Identifiers and Pagination:

Article History:

Article Metrics

CrossRef Citations:

Total Statistics:

Unique Statistics:

Abstract

Objectives:

Method:

Results:

Conclusion:

Track Your Manuscript

Published Contents

About the Editor

About the Journal

The Open Rheumatology Journal

Journal Metrics

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