RESEARCH ARTICLE
Metabolic Factors in Diffuse Idiopathic Skeletal Hyperostosis – A Review of Clinical Data
Sruti Pillai , Geoffrey Littlejohn*
Article Information
Identifiers and Pagination:
Year: 2014Volume: 8
First Page: 116
Last Page: 128
Publisher ID: TORJ-8-116
DOI: 10.2174/1874312901408010116
Article History:
Received Date: 24/4/2014Revision Received Date: 21/10/2014
Acceptance Date: 8/11/2014
Electronic publication date: 19 /12/2014
Collection year: 2014
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Objectives:
We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH.
Method:
We identified studies in our personal database and PubMed using the following keywords in various combinations: “diffuse idiopathic skeletal hyperostosis”, “ankylosing hyperostosis”, “Forestier’s disease”, “diabetes”, “insulin”, “obesity”, “metabolic”, “growth factors”, “adipokines”, “glucose tolerance” and “chondrocytes”.
Results:
We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH.
Conclusion:
Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.
