RESEARCH ARTICLE
The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations
Mikio Kamimura1, Yukio Nakamura*, 2, 3, Shota Ikegami2, Keijiro Mukaiyama2, Shigeharu Uchiyama2, Hiroyuki Kato2
Article Information
Identifiers and Pagination:
Year: 2013Volume: 7
First Page: 112
Last Page: 118
Publisher ID: TORJ-7-112
DOI: 10.2174/1874312920130930003
Article History:
Received Date: 9/8/2013Revision Received Date: 18/9/2013
Acceptance Date: 19/9/2013
Electronic publication date: 29/11/2013
Collection year: 2013

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Objectives:
The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA.
Methods:
We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI) were performed on all cases, and pain was assessed with the Denis pain scale. Average age, height, weight, body mass index, bone mineral density (L1-4), central edge angle, Sharp’s angle, and acetabular hip index were calculated.
Results:
Within two months of the onset of pain, 4 of the 7 cases showed broad bone signal changes, while 3 cases showed local signal changes in the proximal femur on hip MRI. Three to 6 months after the onset of pain, in all patients whose pain was much improved, plain radiographs showed progression to further-stage OA.
Conclusion:
Our findings suggest that bone abnormalities in the proximal femur might be involved in the pathogenesis of primary hip OA.