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JAK Kinases in Health and Disease: An Update
Arian Laurence1
Marko Pesu2 , 3
Olli Silvennoinen2 , 3
John O’Shea, *
, 1
Authors Info & Affiliations
, 1
Authors Info & Affiliations
Abstract
Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.
Keywords: : Jak, tyrosine kinase, kinase inhibitors, autoimunity, myelofibrosis, cancer, cytokine signaling..
