JAK Kinases in Health and Disease: An Update

Laurence, Arian; Pesu, Marko; Silvennoinen, Olli; O’Shea, John

JAK Kinases in Health and Disease: An Update

Arian Laurence¹, Marko Pesu^{2, 3}, Olli Silvennoinen^{2, 3}, John O’Shea^{*, 1}

¹ Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

² Institute of Biomedical Technology, FI-33014 University of Tampere, Finland

³ Centre for Laboratory Medicine, FI-33520 Tampere University Hospital, Finland

Article Information

Identifiers and Pagination:

Year: 2012
Volume: 6
Issue: Suppl 2
First Page: 232
Last Page: 244
Publisher ID: TORJ-6-232
DOI: 10.2174/1874312901206010232

Article History:

Received Date: 13/7/2011
Revision Received Date: 25/6/2012
Acceptance Date: 29/6/2012
Electronic publication date: 7/9/2012
Collection year: 2012

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© Laurence et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; Tel: +1 301-496-2612; Fax: +1 301-480-6372; E-mail: osheajo@mail.nih.gov

Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.

Keywords: : Jak, tyrosine kinase, kinase inhibitors, autoimunity, myelofibrosis, cancer, cytokine signaling..

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RESEARCH ARTICLE

JAK Kinases in Health and Disease: An Update

Article Information

Identifiers and Pagination:

Article History:

Article Metrics

CrossRef Citations:

Total Statistics:

Unique Statistics:

Abstract

Track Your Manuscript

Published Contents

About the Editor

About the Journal

The Open Rheumatology Journal

Journal Metrics

Readership Statistics:

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Press Release

Bentham Open Welcomes Sultan Idris University of Education (UPSI) as Institutional Member

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