Efficacy of Transcranial Direct Current Stimulation Coupled with a Multidisciplinary Rehabilitation Program for the Treatment of Fibromyalgia

Marcelo Riberto*, 1, Fabio Marcon Alfieri2, Kátia Monteiro de Benedetto Pacheco1, Valeria Dini Leite1, Harumi Nemoto Kaihami1, Felipe Fregni3, Linamara Rizzo Battistella1
1 Instituto de Medicina Física e Reabilitação – Universidade de São Paulo, Brazil
2 Universidade Adventista de São Paulo, Brazil
3 Harvard University, Boston, MA, USA

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 2582
Abstract HTML Views: 2483
PDF Downloads: 621
Total Views/Downloads: 5692
Unique Statistics:

Full-Text HTML Views: 1228
Abstract HTML Views: 1355
PDF Downloads: 442
Total Views/Downloads: 3030

Creative Commons License
© Riberto et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, School of Medicine in Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, Monte Alegre CEP14048-900, Ribeirão Preto, SP, Brazil; Tel: (5516) 3602-2416; E-mail:


Pain control in fibromyalgia patients is limited no matter the therapeutic regimens used. Recent data have shown that daily sessions of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in patients with fibromyalgia (FM) are associated with reduction of pain perception.


We aimed to test whether active tDCS, as compared with sham tDCS, combined with multidisciplinary rehabilitation is associated with significant clinical gains in fibromyalgia.


This was a randomized, double-blinded controlled trial.


23 patients were randomized to receive weekly sessions of multidisciplinary rehabilitation approach combined with sham or anodal tDCS of M1. Patients were evaluated for pain with VAS and for quality of life with SF-36, fibromyalgia pain questionnaire and health assessment questionnaire by a blinded rater before and after the 4 month period of rehabilitation.


Patients tolerated tDCS treatment well, without adverse effects. Patients who received active treatment had a significantly greater reduction of SF-36 pain domain scores (F(2,21)=6.57; p=0.006) and a tendency of higher improvement in Fibromyalgia Impact Questionnaire (FIQ) scores after (p=0.056) as compared with sham tDCS/standard treatment, but no differences were observed in the other domains.


Although active tDCS was associated with superior results in one domain (SF-36 pain domain), the lack of significance in the other domains does not fully support this strategy (weekly tDCS) combined with a multidisciplinary approach.

Keywords: Electrical stimulation, cerebral cortex, fibromyalgia, pain, quality of life, rehabilitation..