Synovitis in Spondyloarthritides

Heiner Appel1, Jürgen Braun*, 2
1 Charité Berlin, Campus Benjamin Franklin, Department of Gastroenterology, Infectiology and Rheumatology, Germany
2 Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany

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© Appel and Braun; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Rheumazentrum Ruhrgebiet, Landgrafenstraße 15, D-44652 Herne, Germany; Tel: 49-2325-592130; Fax: 49-2325-592125; E-mail:


Recent studies using magnetic resonance imaging have suggested that the subchondral bone marrow and the entheses are the sites which are primarily involved in the peripheral and axial inflammation found in patients with spondyloarthritides. Histopathological analyses indicated that the typical morphological features at these sites reflect an inflammation (osteitis) at the bone cartilage interface and in the subchondral bone marrow. This finding implies that synovitis may be of minor importance, especially in comparison to other inflammatory joint diseases such as rheumatoid arthritis. Here, we summarize current available knowledge on synovial involvement in inflammatory processes related to SpA.

Keywords: Spondyloarthritides, synovitis, histopathology..