Baricitinib in Rheumatoid Arthritis – Real World Cross-Sectional Study

Sagdeo, Amol; Askari, Ayman; Morrissey, Hana; Ball, Patrick A.

Baricitinib in Rheumatoid Arthritis – Real World Cross-Sectional Study

Amol Sagdeo¹, Ayman Askari¹, Hana Morrissey^{2, *}^iD, Patrick A. Ball²

¹ The Robert Jones & Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, SY10 7AG, England, UK

² School of Pharmacy, University of Wolverhampton, , WV1 1LY, England, UK

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 28
Last Page: 33
Publisher ID: TORJ-14-28
DOI: 10.2174/1874312902014010028

Article History:

Received Date: 16/06/2020
Revision Received Date: 03/09/2020
Acceptance Date: 02/10/2020
Electronic publication date: 25/11/2020
Collection year: 2020

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© 2020 Sagdeo et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

^* Address correspondence to this author at the School of Pharmacy, University of Wolverhampton, WV1 1LY, England, UK; E-mail: hana.morrissey@wlv.ac.uk

Introduction:

Rheumatoid Arthritis (RA) is the most common cause of inflammatory polyarthritis. In RA, increased circulating levels of pro-inflammatory cytokines contribute to the overall symptomatology of fatigue, pain, and joint stiffness. Baricitinib is an orally administered biologic DMARD, used in RA patients, inhibiting signaling via JAK1/JAK2 inhibition, reducing the release of pro-inflammatory cytokines.

Objective:

To explore the efficacy and tolerability for baricitinib in a local population.

Methods:

A cross-sectional study was carried out to review data of RA patients on Baricitinib from the researchers’ own clinic, since its approval in August 2017. The data was collected from an anonymized electronic patient records report. The clinical response was then classified into mild, moderate, and significant improvement.

Results and Discussion:

Overall, 27 out of 37 patients (72.9%) showed clinical improvement with baricitinib. In 9(24.3%) out of 37 patients, the dose had to be reduced to either 2mg/day or 2mg/day - 4mg/day on alternate days. In four of the 9 patients’ where the dose was reduced due to infections (UTI or sinuses), they subsequently experienced fewer infections while maintaining moderate improvement in their RA.

Conclusion:

There is a need for longer-term and larger studies to evaluate the full side effects profile of baricitinib in the local population.

Keywords: Rheumatoid arthritis, Janus associated kinase, Baricitinib, Conventional disease modifying drugs, Biologic disease modifying drugs, UTI.

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RESEARCH ARTICLE

Baricitinib in Rheumatoid Arthritis – Real World Cross-Sectional Study

Article Information

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Abstract

Introduction:

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Conclusion:

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