REVIEW ARTICLE


DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications



Antonio Miranda-Duarte*
Department of Genetics, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Tlalpan, Mexico


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© 2018 Antonio Miranda-Duarte.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Genetics, Instituto Nacional de Rehabilitación, Antonio Miranda-Duarte, Calzada México-Xochimilco 289, Col. Arenal Guadalupe, Deleg. Tlalpan, 14389 México City; Tel: (+52) (55) 59991000; E-mail: fovi01@prodigy.net.mx


Abstract

Background:

Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA.

Objective:

This review is focused on the current status of DNA methylation studies related to OA pathogenesis.

Method:

A review of the literature was conducted on searching in PUBMED for original papers on DNA methylation in OA.

Conclusion:

The DNA methylation research of loci related to OA pathogenesis has shown a correlation between methylation and gene repression; however, there are some exceptions to this rule. Recently, the development of genome-wide methylation and genome-wide hydroxymethylation profiles has demonstrated that several genes previously associated with OA can have changes in their methylation status, favoring the development of the disease, and these have even shown the role of other epigenetic markers.

Keywords: Osteoarthritis, Epigenetics, DNA, Methylation, Cartilage, Chondrocyte.