New Insights on Low Vitamin D Plasma Concentration as a Potential Cardiovascular Risk Factor.
Mattia Bellan1, 2, 3, *, Paolo Marzullo3, 4
Identifiers and Pagination:Year: 2018
Issue: Suppl-1, M6
First Page: 261
Last Page: 278
Publisher Id: TORJ-12-261
Article History:Received Date: 12/02/2018
Revision Received Date: 01/06/2018
Acceptance Date: 12/06/2018
Electronic publication date: 27/12/2018
Collection year: 2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The role of Vitamin D hormone in human health and disease is still debated. Recently, growing attention has been paid to its putative role in cardiovascular system homeostasis with several studies that suggested a correlation between low vitamin D levels and increased cardiovascular risk. Several mechanisms are involved in the development of cardiovascular diseases: systemic inflammation, endothelial dysfunction, arterial hypertension and insulin resistance. In the present paper, we have revised the current literature supporting a role for vitamin D in the development of these pathogenetic processes. Finally, we have evaluated the current evidence linking vitamin D to atherosclerosis and its natural consequence, cardiovascular diseases.