All published articles of this journal are available on ScienceDirect.

REVIEW ARTICLE

Is Male Rheumatoid Arthritis an Occupational Disease? A Review

The Open Rheumatology Journal 27 July 2017 REVIEW ARTICLE DOI: 10.2174/1874312901711010088

Abstract

Background:

Rheumatoid arthritis (RA) is a systemic, inflammatory disease with an estimated global prevalence of 0.3–1.0%. An unexplained association exists between low formal education and the development of RA independent of smoking. It is established that RA is initiated in the lungs and that various occupations associated with dust, fume and metal inhalation can increase the risk of RA development.

Objective:

The objective of this review is to evaluate published clinical reports related to occupations associated with RA development. We highlight the concept of a “double-hit” phenomenon involving adsorption of toxic metals from cigarette smoke by dust residing in the lung as a result of various work exposures. We discuss the relevant pathophysiological consequences of these inhalational exposures in relation to RA associated autoantibody production.

Method:

A thorough literature search was performed using available databases including Pubmed, Embase, and Cochrane database to cover all relative reports, using combinations of keywords: rheumatoid arthritis, rheumatoid factor, anti-citrullinated peptide antibody silica, dust, fumes, metals, cadmium, cigarette smoking, asbestos, mining, bronchial associated lymphoid tissue, heat shock protein 70, and adsorption.

Conclusion:

We postulate that the inhalation of dust, metals and fumes is a significant trigger factor for RA development in male patients and that male RA should be considered an occupational disease. To the best of our knowledge, this is the first review of occupations as a risk factor for RA in relation to the potential underlying pathophysiology.

Keywords: Silica, Dust, Occupation, Inhalation, Cadmium, Cigarette smoking, Bronchial associated lymphoid tissue, Adsorption, Rheumatoid arthritis.
Fulltext HTML PDF ePub
1800
1801
1802
1803
1804