New Insights on Low Vitamin D Plasma Concentration as a Potential Cardiovascular Risk Factor.
Mattia Bellan1, 2, 3, *, Paolo Marzullo3, 4
The role of Vitamin D hormone in human health and disease is still debated. Recently, growing attention has been paid to its putative role in cardiovascular system homeostasis with several studies that suggested a correlation between low vitamin D levels and increased cardiovascular risk. Several mechanisms are involved in the development of cardiovascular diseases: systemic inflammation, endothelial dysfunction, arterial hypertension and insulin resistance. In the present paper, we have revised the current literature supporting a role for vitamin D in the development of these pathogenetic processes. Finally, we have evaluated the current evidence linking vitamin D to atherosclerosis and its natural consequence, cardiovascular diseases.
Correspondence: Address Correspondence to this author at the Università del Piemonte Orientale UPO, via Solaroli 17, 28100 Novara, Italy; E-mail:firstname.lastname@example.org