Plasma Saturated and Monounsaturated Fatty Acids in Behçet’s Disease

Meriam Messedi1, *, Manel Naifar2, Sahar Grayaa1, Faten Frikha3, Mariem Messoued1, Mohamed Marouene Sethom4, Moncef Feki4, Naziha Kaabach4, Zouheir Bahloul3, Kamel Jamouss1, Fatma Ayedi1, 2
1 Unit of Research «Molecular Bases of Human Diseases», 12ES17, Faculty of Medicine of Sfax, University of Sfax 3029, Tunisia
2 Biochemistry laboratory, Habib Bourguiba University Hospital, Sfax 3029, Tunisia
3 Internal Medicine Department, Hedi Chaker Hospital, Sfax- Tunisia
4 UR05/08-08, Biochemistry laboratory, La Rabta Hospital and Faculty of Medicine of Tunis, Tunis 1007, Tunisia



Fatty acid (FA) composition of serum has been associated with many markers of inflammation. In this study, we tried to examine plasma saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) composition in Behçet's disease (BD) patients. The associations between the circulating FA levels and some markers of inflammation have also been investigated.


This study is a cross-sectional one. In fact, a total of 101 BD patients and healthy controls group of 99 subjects are enrolled. Gas Chromatograph equipped with a Capillary Split/Splitless Injector and flame ionization detector was used to analyze the plasma SFA and MUFA compositions. The high sensitivity C-reactive protein (hsCRP) and fibrinogen levels were measured using standard techniques.


BD patients had significantly higher proportions of mystiric acid (MA), palmitic acid (PAM), palmitoleic acid (POA) and stearoyl-CoA desaturase (SCD)-16, compared to controls.

The results revealed that patients with severe involvements had high levels of POA and total MUFA associated with higher SCD-16 activity compared to those with minor ones. The receiver operator characteristic curve analysis revealed that POA could well discriminate BD patients with severe clinical manifestations. In the bivariate analysis, hsCRP was found to be positively correlated with total SAFA and POA elongase activity index but negatively correlated with SCD-18 activity index. The STA, POA, elongase and SCD-16 activity index are correlated with fibrinogen. On the other hand, the multivariate analysis showed that POA remained associated with higher levels of hsCRP.


Unfavourable plasma SFA and MUFA profile were reported in BD patients. POA, which is associated with higher plasma hsCRP level, may play a role in the pathogenesis of BD.

Keywords: Behçet’s disease, Plasma saturated fatty acids, Plasma monounsaturated fatty acids,stearoyl-CoA desaturase, Inflammation, C reactive proteine.

Abstract Information

Identifiers and Pagination:

Year: 2018
Volume: 12
Publisher Item Identifier: EA-TORJ-2018-7

Article History:

Received Date: 14/3/2018
Revision Received Date: 9/6/2018
Acceptance Date: 28/6/2018
Electronic publication date: 20/7/2018
Collection year: 2018

© 2018 Messedi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Correspondence: Address for correspondence to this auther at the Unit of Research «Molecular Bases of Human Diseases», 12ES17, Faculty of Medicine of Sfax, University of Sfax 3029, Tunisia; Tel: +00 216 98657098; E-mail: